MPRAnalyze

Statistical framework for data generated by MPRAs

MPRAnalyze is an analysis framework designed for data generated by Massively Parallel Reporter Assays (MPRAs). MPRAnlayze can be used for quantification of enhancer-induced transcription rates, calssification of active\inactive enhancers, and comparative analyses of enhancer activity between conditions.

Please checkout the project on GitHub or on Bioconductor.



Relevant publications

LentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements.
Gordon, M. G., Inoue, F., Martin, B., Schubach, M., Agarwal, V., Whalen, S., Feng, S., Zhao, J., Ashuach, T., Ziffra, R., Kreimer, A., Georgakopoulous-Soares, I., Yosef, N., Ye, C. J., Pollard, K. S., Shendure, J., Kircher, M., & Ahituv, N.

Nature Protocols

 10.1038/s41596-020-0333-5
MPRAnalyze—A statistical framework for Massively Parallel Reporter Assays.
T. Ashuach*, DS Fischer*, FJ Theis, N. Yosef.

Genome Biology

 10.1186/s13059-019-1787-z