Prediction of epigenetic events using chromatin accessibility

Epitome leverages chromatin accessibility (either DNase-seq or ATAC-seq) to predict epigenetic events in a novel cell type of interest. Such epigenetic events include transcription factor binding sites and histone modifications. Epitome computes chromatin accessibility similarity between ENCODE cell types and the novel cell type, and uses this information to transfer known epigentic signal to the novel cell type of interest.

You can view and install the tool from GitHub.

Relevant publications

Epitome: predicting epigenetic events in novel cell types with multi-cell deep ensemble learning.
A.K. Morrow, J.W. Hughes, J. Singh, A.D. Joseph, N. Yosef
Nucleic Acids Research , 2021